Maybe it’s not about humans and never has been. Maybe by the time the gods realized how much of an issue humans were, we were already too widespread for them to destroy us without either running out of mana or ruining earth for everything.
Maybe the cancer is a god’s plan, but it’s not working well enough.
Is it a collection of games or more of a mashup? Ie, do you get a menu where you pick one of many games that are independent of each other, or is there an overall narrative (or something) that ties them all together like the NES remix packs?